>gi|4507751|ref|NP_001062.1| thymidylate synthase [Homo sapiens]
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR
ILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
>gi|114672493|ref|XP_001150558.1| PREDICTED: hypothetical protein isoform 5 [Pan troglodytes]
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIEHILRCGVRKDDRTGTGTLSVFGMQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKSNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLK
ILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
>gi|57100565|ref|XP_533309.1| PREDICTED: similar to Thymidylate synthase (TS) (TSase) [Canis familiaris]
MPAPGSELQRPPSPPAAQKPRARPQPPPHGELQYLGQVEHILSCGARKHDRTGTGTLSVFGMQARYSLRD
EFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSRGVKIWDANGSRDFLDSLGFANREEGDLGPIYGFQW
RHFGAEYKDKDSDYSGQGVDQLQKVIDTIKTNPDDRRIILCGWNPKDLPLMALPPCHALCQFYVVNGELS
CQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKL
RILRRVEKIDDFKAEDFQIEGSANFKNYTSAVNPKFEQAEEHQHS
>gi|73961995|ref|XP_849163.1| PREDICTED: similar to Thymidylate synthase (TS) (TSase) [Canis familiaris]
MPAPGSELQRPPSPPAAQKPRARPQPPPHGELQYLRQVEHILSCGARKHDRTGTGTLSVFGMQARYSLRD
EFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSRGVKIWDANGSRDFLDSLGFANREEGDLGPIYGFQW
RHFGAEYKDKDSDYSGQGVDQLQKVIDTIKTNPDDRRIILCGWNPKDLPLMALPPCHALCQFYVVNGELS
CQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKL
RILRRVEKIDDFKAEDFQIEGSANFKNYTSAVNPKFEQAEEHQHS
>gi|83716002|ref|NP_001032905.1| thymidylate synthase [Bos taurus]
MPAAGSEPSRPPSPPGVQEQSAEPRPPPPPHGELQYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNL
RDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDGLGFSDRAEGDLGPVYGF
QWRHFGAEYKDMDSEYSGQGVDQLQKVIDTIKTNPNDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGE
LSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDAHIYLNHIEPLKTQALMELRGQS
SRSLDGDGQAGTSRWAPVATDTERDRCCELQREPRPFPKLKILRKVETIDDFQAEDFQIEGYNPNPTIKM
EMAV
>gi|46358062|ref|NP_067263.1| thymidylate synthase [Mus musculus]
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTT
KRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY
KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRS
GDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVE
TIDDFKVEDFQIEGYNPHPTIKMEMAV
>gi|9507217|ref|NP_062052.1| thymidylate synthase [Rattus norvegicus]
MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTT
KRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADY
KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRS
GDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVE
TIDDFKVEDFQIEGYNPHPTIKMEMAV
>gi|118086858|ref|XP_419147.2| PREDICTED: similar to Chain A, Human Thymidylate Synthase Complexed With Dump And Raltitrexed, An Antifolate Drug, Is In The Closed Conformation [Gallus gallus]
MPAAEEPSSGLEGGEPQYLQQVRHILQHGHRKEDRTGTGTISVFGMQARYSLRDQFPLLTTKRVFWKGVL
EELLWFIKGSTNAKELSAKGVKIWDANGSREFLDKQGFCTREEGDLGPVYGFQWRHFGADYKDMHTDYSN
QGVDQLQKVIEMIKTNPDDRRIIMCAWNPKDISLMALPPCHALCQFYVLNGELSCQLYQRSGDMGLGVPF
NIASYSLLTYMIAHVTGLKPGEFIHTLGDAHIYLNHVEPLKVQLQREPRPLPKLRILRKVEDISDFKAED
FQIEDYNPHPPIKMEMAV
>gi|18859519|ref|NP_571835.1| thymidylate synthase [Danio rerio]
MPDTAVEVTNGHCVNGESKKEETNGGKKEFSLFCDERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQAR
YSLRDQFPLLTTKRVFWKGILEELLWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPV
YGFQWRHFGAEYKDMHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVS
NGELSCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYTNHIEPLKEQIQREPR
PFPKLRIKRKVEQINDFCAEDFEIYDYDPHPTIKMQMAV
>gi|17137556|ref|NP_477367.1| Ts [Drosophila melanogaster]
MVLTPTKDGPDQESMPLPADNGESPSKQQAPVNRDEMHYLDLLRHIIANGEQRMDRTEVGTLSVFGSQMR
FDMRNSFPLLTTKRVFFRAVAEELLWFVAGKTDAKLLQAKNVHIWDGNSSREFLDKMGFTGRAVGDLGPV
YGFQWRHFGAQYGTCDDDYSGKGIDQLRQVIDTIRNNPSDRRIIMSAWNPLDIPKMALPPCHCLAQFYVS
EKRGELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKPGDFVHTMGDTHVYLNHVEPLKEQLERT
PRPFPKLIIKRQVQDIEDFRFEDFQIVDYNPHPKIQMDMAV
>gi|118781473|ref|XP_311491.3| AGAP010457-PA [Anopheles gambiae str. PEST]
MEGENGNVVKKDNGNEEEQAYLQLIRDIINKGSKRLDRTGVGTLSIFGAQMRFSLRDGIIPLLTTKKVFF
RGVAEELLWFIKGSTNVKDLQAKGVRIWDGNSTREYLDSCGFTDREEGDLGPVYGFQWRHFGATYKTCHD
DYTGQGIDQLAEVIDKIKNNPYDRRIIMCAWNPSDIPNMALPPCHCLAQFFVSDGELSCQMYQRSADVGL
GVPFNIASYSLLTHMIAHVTGLKAGEFIHTTGDTHIYLNHVDGLREQIERTPKKFPTLVFKRKVESIDNF
TYDDFEILNYNPQSAIKMKMAV
>gi|71993377|ref|NP_491532.3| hypothetical protein Y110A7A.4 [Caenorhabditis elegans]
MNKENIIADAPSDVVKTVQQQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTI
PLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRH
FGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQ
LYQRSGDMGLGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRF
TRDVASIDDFTSDMIALDDYKCHPKIPMDMAV
>gi|19115217|ref|NP_594305.1| thymidylate synthase (predicted) [Schizosaccharomyces pombe 972h-]
MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPAR
NFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLI
RAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVA
DKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPS
TTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDR
TGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFL
DSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIP
EMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHV
MGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV
>gi|83578104|ref|NP_014717.2| Cdc21p [Saccharomyces cerevisiae S288c]
MTMDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIILEL
LWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKYKTCDDDYTGQGI
DQLKQVIHKLKTNPYDRRIIMSAWNPADFDKMALPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDM
GLGVPFNIASYALLTRMIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDID
DFKLTDFEIEDYNPHPRIQMKMSV
>gi|50302825|ref|XP_451349.1| hypothetical protein [Kluyveromyces lactis NRRL Y-1140]
MTLSDENVKRVKLEAVNAEEQQYLDLCERIINEGEFRPDRTGTGTYSLFAPPQLRFNLSNDTFPLLTTKR
VFTKGIILELLWFVAGCTDGKKLSEQGVKIWEGNGSREYLDSLGLTDRREGDLGPVYGFQWRHFGAEYKT
CDDDYSGQGVDQLKEIIHKLKTNPYDRRIILSAWNPPDFPKMALPPCHVFSQFYVSFPKGEGAKPRLSCV
LYQRSCDMGLGVPFNIASYALLTKMIAMVCDMEPGEFIHTLGDAHVYKDHVDALRTQIAREPRAFPKLKI
KRNVSDIDDFKYEDFEITDYNPHGKIQMKMSV
>gi|45188092|ref|NP_984315.1| ADR219Cp [Ashbya gossypii ATCC 10895]
MSWRSLKDPTYARQAHYIYQLTLQRNMGLPNLKMDSVKSDTRSSVNAEEQQYLDLCKRIIEHGEFRPDRT
GTGTYSLFAPPQLRFDLSGDKFPLLTTKKVFTRGIILELLWFIAGCTDGKKLSEQGVKIWEGNGSREYLD
GLGLHDRREGDLGPVYGFQWRHFGAEYGTCDDDYTGKGVDQLRELIDKIKNKPYDRRIILSAWNPADFPK
MALPPCHVLSQFYVSFGPEGSRPKLSCQLYQRSCDMGLGVPFNIASYALLTKMIAMVCDMDAGEFIHTMG
DAHVYSDHIAALKEQIERVPREFPNLRIKRKVTDIDDFTLDDFEITDYNPHPRIQMNMSV
>gi|39944952|ref|XP_362013.1| hypothetical protein MGG_04458 [Magnaporthe oryzae 70-15]
MADAGAKPAQNGTERHEEYQYLDLVREILDNGEHRPDRTGTGTYSIFAPRPLKFSLNKDGTPILPLLTTK
RVFSRAVILELLWFVSGATSAKPLSDAGVKIWDGNGSREFLDGLGLQHREVGDLGPVYGFQWRHFGAEYT
DCHADYTGQGVDQLAEVVHKLRTNPYDRRMVLSAWNPKDLKLMVLPPCHMFAQFYVSYPKAGSDSNGNGN
TTEGADQTSSPSKPKGHLHCQLYQRSCDMGLGVPFNIASYALLTHMIARATGLVPGSLTHVMGDAHVYAD
HVDALRTQLEREPRPFPELEINRPEVPEGGDGVIDGWKLEDFVIKGYDPHKAIAMKMSV
>gi|85089414|ref|XP_957941.1| thymidylate synthase [Neurospora crassa OR74A]
MTVTTSEPVAPAQSQSQTSSRTNPTSKRHEEYQYLDLVRQILDEGELREDRTGTGTYSIFAPTPLKFALS
RPSSSSPSSGSSSDPSSPDYTYTPILPLLTTKRVFTKAVLLELLWFISASTSSTTLSAQGVKIWDGNGSR
AFLDMLGLSHRKEGDLGPVYGFQWRHFGAEYVDCETDYTGQGVDQLQRIIDTLRNNPYDRRLILSAWNPK
DMSQMVLPPCHMFAQFYVSYPGSRTRGGATQTQNKEGELDTPPKEKKPRGHLHCQLYQRSCDMGLGVPFN
IASYALLTHMLAHVCDLVPGSLTHVMGDAHVYLNHVDALKTQLEREPREFPTLEIQREKGGSIDGWKAED
FVIKGYEPHKTIAMEMSV
>gi|30690081|ref|NP_195183.2| THY-2 (thymidylate synthase 2); dihydrofolate reductase/ thymidylate synthase [Arabidopsis thaliana]
MRCLQNSAKTLPLAFKSALLPLSQRWFCKFSPKPSSLTNIFKVSISTMANTLNGNVIMTSKPQSTYQVVV
AATKEMGIGKDGKLPWNLPTDLKFFKDLTLSTSDSAKKNAVVMGRKTWESIPKKYRPLSGRLNVVLSRSS
GFDIANTENVVTCSSIDSALDLLAAPPFSLSIEKVFVIGGGDILREALNKPSCEAIHITEIDTSIDCDTF
IPTVDTSAYQPWCSSFPICENGLRFSFTTHVRVKSSSAGEASDESDGSKVLQVDWKKFSSVLPKMIFDRH
EEYLYLNLVKEIISNGNLKDDRTGTGTLSKFGCQMKFNLRRNFPLLTTKRVFWRGVVEELLWFISGSTNA
KVLQEKGIRIWDGNASRAYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKI
KNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILA
HVCDLVPGDFIHVIGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKKID
MKMAV
>gi|15227185|ref|NP_179230.1| THY-1 (THYMIDYLATE SYNTHASE 1); dihydrofolate reductase/ thymidylate synthase [Arabidopsis thaliana]
MATTTLNDSVTTTLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVVMG
RKTWESIPIKYRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGDIL
REALNRPSCDAIHLTEIDTSVDCDTFIPAIDTSVYQPWSSSFPVTENGLRFCFTTFVRVKSSADESSDES
NGSQSLQFDGKKFLFLPKMVFDQHEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLL
TTKRVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGA
KYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQ
RSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHVLGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPE
KKQIDSFVASDFDLTGYDPHKKIEMKMAV
>gi|115485535|ref|NP_001067911.1| Os11g0484400 [Oryza sativa (japonica cultivar-group)]
MTWPNKRYYLLPSLLSIRTKSLKKKRKENPPFHTNLYSPPSQFPICSGGGERDTAAAAAALRRTRPGGAR
RGTDTSTTLPLFLSFLTPQPPTPDPRPPSRFIRAASIPSRRLESNRRIQMLVAEVFRAGAYISRFSRHAC
QVARFSGISCAPISQFRRPQSLEGSRKLRSCCFIQTRLIAMATTLSNGVSQNGPQRNYQVVVAATRDMGI
GKDGVLPWKLLGDLKFFKELTVTTADPVKKNAVIMGRKTWESLPLKARPLPGRLNIILTRSGSFEFATVE
NVVICGSMNSALELLSSTPYCLSIEKVFVIGGGQVLRESLNGPSCEAVHLTDIQSSIECDTFIPPIDLSV
FQPWYSSLPVVESNIRHSFVTYVRVRKTMAETHDSNGKESANDGIKSDKFETENFSFLPKLIFDRHEEYH
YLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQ
EKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGAEYTDMHADYTGKGFDQLMDVIDKIKNNP
DDRRIILSAWNPSDLKKMALPPCHMFAQFYVESGELSCQMYQRSADMGLGVPFNIASYSLLTYMIAHVCG
LSPGEFVHVIGDAHVYRTHVRALEEQIQKLPKPFPVLKINPLKKDIDSFVASDFKLVAKLGPPVTM
>gi|115488458|ref|NP_001066716.1| Os12g0446900 [Oryza sativa (japonica cultivar-group)]
MPVPNPHSPGLSGKNPMPVPMSDGNGYARRATHFFRKSNILILRLQSLKYLEFRDKLNFSRFHKSQVIVM
STNVNNGNSESNLKRSYQVVVSATRDMGIGKDGTLPWKLPGDLKFFKDITVTTSDPSKKNAVVMGRKTWE
SIPLKFRPLPGRLNVILTRSGSFDFATAENVVICGSLDSALQLLATTPYCLTVEKTFIIGGGEILRQSLN
APACEAIHLTDIESSIECDTFIPPIDLSMFHPWYSSFPVVENGIKHSFISFVRVTKSIAEANDSSGKELT
GNDSKKVKFEIENFSFLPKMIFERHEEYQYLNLVQDIIRNGAKKNDRTGTGTVSKFGCQMRFNLRRNFPL
LTTKRVFWRGVLEELLWFISGSTNAKVLQEKGIHIWDGNASRQYLDRYTDMHADYVGKGFDQLMDVIDKI
KNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIA
QVCDLSPGDFVHVIGDAHVYRTHVEALEEQMRKQPKPFPILKINPVKKDIDSFVTSDFKLVRYDPHHKIE
MKMAQIQLEPF
>gi|124505475|ref|XP_001351479.1| bifunctional dihydrofolate reductase-thymidylate synthase [Plasmodium falciparum 3D7]
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKY
EKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDV
YIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISV
SDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYEN
DDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGV
LSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH
REVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPC
HILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSL
KIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA